Simultaneous inhibition of FLT3 and HDAC by novel 6-ethylpyrazine-2-Carboxamide derivatives provides therapeutic advantages in acute myelocytic leukemia
Yingjie Chang, Xue Li, Yue Zhou, Xinying Yang, Wei Zhao, Hao Fang, Xuben Hou
Topics & Concepts
ChemistryVorinostatHistone deacetylasePharmacophoreFms-Like Tyrosine Kinase 3CarboxamideCancer researchPharmacologyHistone deacetylase inhibitorBiochemistryHistoneBiologyMutationGeneHistone Deacetylase Inhibitors ResearchAcute Myeloid Leukemia ResearchProtein Degradation and Inhibitors