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Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans

Gwladys Gernoux, Alisha M. Gruntman, Meghan Blackwood, Marina Zieger, Terence R. Flotte, Christian Mueller

2020Molecular Therapy43 citationsDOIOpen Access PDF

Topics & Concepts

CapsidTransgeneGenetic enhancementGene deliveryBiologyVector (molecular biology)Viral vectorRecombinant DNAPharmacologyGene transferImmunologyVirologyCell biologyMedicineVirusGeneGeneticsVirus-based gene therapy researchCAR-T cell therapy researchViral Infections and Immunology Research
Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans | Litcius