Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
Giulia Montagner, Silvia Dominici, Simona Piaggi, Alfonso Pompella, Alessandro Corti
Abstract
Boric acid (BA) is the dominant form of boron in plasma, playing a role in different physiological mechanisms such as cell replication. Toxic effects have been reported, both for high doses of boron and its deficiency. Contrasting results were, however, reported about the cytotoxicity of pharmacological BA concentrations on cancer cells. The aim of this review is to briefly summarize the main findings in the field ranging from the proposed mechanisms of BA uptake and actions to its effects on cancer cells.
Topics & Concepts
Boric acidCytotoxicityCancer cellBoronChemistryCancerCancer researchCellPharmacologyBiophysicsCell biologyBiochemistryIn vitroBiologyInternal medicineMedicineOrganic chemistryBoron Compounds in ChemistryTrace Elements in HealthPlant Micronutrient Interactions and Effects