Human Blastomycosis in South Africa Caused by<i>Blastomyces percursus</i>and<i>Blastomyces emzantsi</i>sp. nov., 1967 to 2014
Tsidiso G. Maphanga, Monica Birkhead, José F. Muñoz, Mushal Allam, Thokozile G. Zulu, Christina A. Cuomo, Ilan S. Schwartz, Arshad Ismail, Serisha D. Naicker, Ruth Mpembe, Craig Corcoran, Sybren de Hoog, Chris Kenyon, Andrew M. Borman, John Frean, Nelesh P. Govender
Abstract
We reevaluated 20 cases of blastomycosis diagnosed in South Africa between 1967 and 2014, with Blastomyces dermatitidis considered to be the etiological agent, in light of newly described species and the use of more advanced technologies. In addition to histopathological and/or culture-based methods, all 20 isolates were phenotypically and genotypically characterized, including multilocus typing of five genes and whole-genome sequencing.
Topics & Concepts
BlastomycesBlastomycosisBlastomyces dermatitidisMicrobiologyBiologyVirologyImmunologyFungal Infections and StudiesAntifungal resistance and susceptibilityMycobacterium research and diagnosis