Diverse <i>meta</i>-C–H Functionalization of Amides
Aniket Gholap, Sukdev Bag, Sukumar Pradhan, Anant R. Kapdi, Debabrata Maiti
Abstract
Overriding the preference for favorable proximal metalation by ortho-directing amide group, a pyrimidine-based directing group (DG) has been demonstrated for diverse remote meta-C–H functionalizations of arenes including allylation, cyanation, alkylation, alkynylation, and deuteration. The scope of palladium-catalyzed meta-C–H functionalizations has been presented with various pharmaceutically relevant phenylacetic acid, hydrocinnamic acid, and naphthylacetic acid derivatives.
Topics & Concepts
MetalationCyanationPhenylacetic acidChemistryAmideSurface modificationAlkylationPalladiumCatalysisCombinatorial chemistryPyrimidineAlkynylationStereochemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic ChemistryCatalytic Cross-Coupling Reactions