Generation of the tumor-suppressive secretome from tumor cells
Shengzhi Liu, Xun Sun, Kexin Li, Rongrong Zha, Feng Yan, Tomohiko Sano, Chuanpeng Dong, Yunlong Liu, Uma K. Aryal, Akihiro Sudo, Bai‐Yan Li, Hiroki Yokota
Abstract
The tumor-suppressive secretome can be generated from tumor cells, in which β-catenin presented two opposing roles, as an intracellular tumor promoter in tumor cells and a generator of extracellular tumor suppressor in CM. Eno1 was enriched in CM and its interaction with CD44 was involved in Eno1's anti-tumor action. Besides presenting a potential option for treating primary cancers and metastases, the result indicates that aggressive tumors may inhibit the growth of less aggressive tumors via tumor-suppressive secretomes.
Topics & Concepts
Cancer researchWnt signaling pathwayCD44Tumor microenvironmentPancreatic cancerCancer cellTumor progressionImmune systemDownregulation and upregulationBiologyCancerChemistryPathologyMedicineSignal transductionCell biologyCellImmunologyInternal medicineTumor cellsGeneticsBiochemistryGeneWnt/β-catenin signaling in development and cancerUbiquitin and proteasome pathwaysCancer-related gene regulation