Assembly of catechol-modified polymer brushes for drug delivery
Kaijie Zhao, Zhiliang Gao, Dongpo Song, Peiyu Zhang, Jiwei Cui
Abstract
The anticancer drug of Bortezomib conjugated onto catechol-modified bottlebrush block copolymers can be intracellularly released owing to the pH-responsive behavior, resulting in considerable cell death and tumor growth inhibition.
Topics & Concepts
CatecholConjugated systemBortezomibDrugChemistryCopolymerDrug deliveryPolymerCombinatorial chemistryBiophysicsPharmacologyBiochemistryOrganic chemistryMedicineBiologyMultiple myelomaInternal medicinePolymer Surface Interaction StudiesNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers