Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation
Qiang Chen, Jianlong Du, Kun Cui, Wei Fang, Zengqi Zhao, Qiuchi Chen, Kangsen Mai, Qinghui Ai
Abstract
octanoate stimulation further verified that acetyl-CoA derived from fatty acid β-oxidation mediated acetylation homeostasis in the nucleus. The broad therapeutic prospects of intermediate metabolites and acetyltransferases/deacetylases might provide critical insights for the treatment of metabolic diseases in vertebrates.
Topics & Concepts
AcetylationAcetyltransferasesBeta oxidationInflammationChemistryBiochemistryMitochondrionNAD+ kinaseAcetyl-CoAProinflammatory cytokineCell biologyFatty acidBiologyMetabolismEnzymeGeneImmunologyAdipose Tissue and MetabolismSirtuins and Resveratrol in MedicinePeroxisome Proliferator-Activated Receptors