Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease
Feng He, Yingying Ran, Xiaoyang Li, Defeng Wang, Qiuqiong Zhang, Jiahui Lv, Chenggong Yu, Ying Qu, Xiangna Zhang, Ana Xu, Chao Wei, C. James Chou, Jingde Wu
Topics & Concepts
MemantineChemistryNMDA receptorPharmacologyCytotoxicityMoietyInhibitory postsynaptic potentialIC50ReceptorIn vitroBiochemistryNeuroscienceStereochemistryMedicineBiologyHistone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative DiseasesPhosphodiesterase function and regulation