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Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease

Feng He, Yingying Ran, Xiaoyang Li, Defeng Wang, Qiuqiong Zhang, Jiahui Lv, Chenggong Yu, Ying Qu, Xiangna Zhang, Ana Xu, Chao Wei, C. James Chou, Jingde Wu

2020Bioorganic Chemistry28 citationsDOI

Topics & Concepts

MemantineChemistryNMDA receptorPharmacologyCytotoxicityMoietyInhibitory postsynaptic potentialIC50ReceptorIn vitroBiochemistryNeuroscienceStereochemistryMedicineBiologyHistone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative DiseasesPhosphodiesterase function and regulation
Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease | Litcius