Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome
Martina Parrini, Shovan Naskar, Micol Alberti, Ilaria Colombi, Giovanni Morelli, Anna Rocchi, Marina Nanni, Federica Piccardi, Séverine Charles, Giuseppe Ronzitti, Federico Mingozzi, Andrea Contestabile, Laura Cancedda
Topics & Concepts
Gene knockdownIntracellularTransporterBiologyHomeostasisRNA interferenceGene silencingIn vivoNeurosciencePharmacologyCell biologyBiochemistryGeneRNAGeneticsDown syndrome and intellectual disability researchAnalog and Mixed-Signal Circuit DesignNeonatal and fetal brain pathology