HIV-1 propagation is highly dependent on basal levels of the restriction factor BST2
Balaji Olety, Paul J. Peters, Yuanfei Wu, Yoshiko Usami, Heinrich G. Göttlinger
Abstract
populations can be fully rescued by exogenous BST2 irrespective of its capacity to signal and even by an artificial BST2-like protein that shares its virion entrapment activity but lacks sequence homology. Counterintuitively, our results reveal that HIV-1 propagation is critically dependent on basal levels of virion tethering by a key component of innate antiviral immunity.
Topics & Concepts
Basal (medicine)Human immunodeficiency virus (HIV)BiologyFactor (programming language)Computer scienceVirologyEndocrinologyInsulinProgramming languageHIV Research and TreatmentHIV/AIDS Research and InterventionsCRISPR and Genetic Engineering