Cu-Catalyzed radical-triggered spirotricyclization of enediynes and enyne-nitriles for the synthesis of pentacyclic spiroindenes
Hang‐Dong Zuo, Xiao-Shuang Ji, Cheng Guo, Shu‐Jiang Tu, Wen‐Juan Hao, Bo Jiang
Abstract
A new copper-catalyzed radical-triggered fluoromethylation-spirotricyclization of enediyne- and enyne-nitrile-containing<italic>para</italic>-quinone methides (<italic>p</italic>-QMs) was reported for the first time, and used to produce a series of hitherto unreported pentacyclic spiroindenes.
Topics & Concepts
EnediyneChemistryNitrileEnyneCatalysisQuinoneStereochemistryCopperCombinatorial chemistryOrganic chemistryCyclization and Aryne ChemistrySynthesis of Indole DerivativesCarbohydrate Chemistry and Synthesis