Glycogen Metabolism in Candida albicans Impacts Fitness and Virulence during Vulvovaginal and Invasive Candidiasis
Jian Miao, Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael Kruppa, Brian M. Peters
Abstract
starvation and the colonization of the mouse vagina. Moreover, a global glycogen catabolism mutant is rendered less virulent during murine invasive candidiasis. Therefore, this work demonstrates that glycogen metabolism in C. albicans contributes to survival and virulence in the mammalian host and may be a novel antifungal target.
Topics & Concepts
Candida albicansVirulenceVulvovaginal CandidiasisGlycogenMicrobiologyBiologyMedicineEndocrinologyBiochemistryGeneAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentBreastfeeding Practices and Influences