A new method for treating chronic pancreatitis and preventing fibrosis using bioactive calcium silicate ion solution
Hua Yin, Zhaowenbin Zhang, Deyu Zhang, Lisi Peng, Chuanchao Xia, Xiao-Li Yang, Xinyue Wang, Zhao‐Shen Li, Jiang Chang, Haojie Huang
Abstract
ions to inhibit inflammation and fibrosis and promote acinar regeneration. The possible mechanism of the therapeutic effect of CS ion solution mainly includes the inhibition of PAC apoptosis by down-regulating the c-caspase3 signal pathway and promotion of the regeneration of PACs by up-regulating the WNT/β-catenin signaling pathway. In addition, the CS ion solution also effectively down-regulated the NF-κB signaling pathway to reduce macrophage infiltration and PAC inflammatory factor secretion, thereby reducing PSC mediated pancreatic fibrosis. This bioceramics-based ion solution provides a new idea for disease treatment using biomaterials, which may have the potential for the development of new therapy for CP.