Role of RASA1 in cancer: A review and update (Review)
Yanhua Zhang, Yue Li, Quanyue Wang, Bo Su, Hui Xu, Yang Sun, Pei Sun, Rumeng Li, Xiaochun Peng, Jun Cai
Abstract
Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours.
Topics & Concepts
OncogeneCell cycleMAPK/ERK pathwayPI3K/AKT/mTOR pathwayAngiogenesisCancer researchProtein kinase BRegulatorApoptosisBiologyActivator (genetics)Cell growthCancerCell biologyCellSignal transductionBiochemistryReceptorGeneticsGeneRNA modifications and cancerMicroRNA in disease regulationRNA Research and Splicing