Cp*Ir(<scp>iii</scp>)- and Cp*Rh(<scp>iii</scp>)-catalyzed C(sp<sup>2</sup>)–H amination of arenes using thioethers as directing groups
Hui Xie, Mei Zhong, Xiaotong Wang, Jia‐Qiang Wu, Yanqu Cai, Jidan Liu, Bing Shu, Tong Che, Shang‐Shi Zhang
Abstract
A mild and selective Cp*Ir(<sc>iii</sc>)- and Cp*Rh(<sc>iii</sc>)-catalyzed direct C(sp<sup>2</sup>)–H amination of arenes and three types of nitrene precursor reagents is reported, with the assistance of a thioether directing group.
Topics & Concepts
ChemistryNitreneThioetherAminationCatalysisReagentMedicinal chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques