Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation–inert complex
Cecilia Wallin, Jüri Jarvet, Henrik Biverstål, Sebastian K.T.S. Wärmländer, Jens Danielsson, Astrid Gräslund, Axel Abelein
Abstract
weak metal-ion binding, quantitatively linking the contributions of specific interactions of metal ions with monomeric Aβ to their effects on bulk aggregation.
Topics & Concepts
MonomerFibrilPeptideChemistryDivalentMetalBiophysicsMetal ions in aqueous solutionAmyloid (mycology)CrystallographyBiochemistryInorganic chemistryPolymerOrganic chemistryBiologyAlzheimer's disease research and treatmentsSupramolecular Self-Assembly in MaterialsDrug Transport and Resistance Mechanisms