Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19
Jianwei Zhang, Yuan Xiong, Feng Wang, Fu-Mao Zhang, Xiaodi Yang, Guo‐Qiang Lin, Ping Tian, Guangbo Ge, Dingding Gao
Topics & Concepts
ChemistryDocking (animal)PeptidomimeticIC50PharmacologyCysteine proteaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)EnzymeCoronavirusStructure–activity relationshipCoronavirus disease 2019 (COVID-19)ProteaseBiochemistryDrug discoveryStereochemistryIn vitroInfectious disease (medical specialty)PeptideBiologyDiseasePathologyNursingMedicineComputational Drug Discovery MethodsAntimicrobial Peptides and ActivitiesSARS-CoV-2 and COVID-19 Research