Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV—workshop report
Milton Maciel, Rama Rao Amara, Katharine J. Bar, Shane Crotty, Steven G. Deeks, Christopher Duplessis, Gaurav D. Gaiha, M. Juliana McElrath, Andrew J. McMichael, Amy Palin, Rachel L. Rutishauser, Stuart Z. Shapiro, Stephen T. Smiley, M. Patricia D’Souza
Abstract
The US National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institute of Health (NIH), convened a virtual workshop on August 8-9th, 2023 to explore potential synergies between HIV vaccine approaches that are designed to induce cellular or humoral immune responses. The goal of this workshop was to review data on leading vaccine candidates and to discuss the best strategies for combining these approaches to optimize immunity against HIV. Here, we summarize the findings reviewed at the workshop and discuss the knowledge gaps and priorities for future studies that will help accelerate the development of a preventive HIV vaccine.