Antimicrobial peptide-conjugated phage-mimicking nanoparticles exhibit potent bactericidal action against <i>Streptococcus pyogenes</i> in murine wound infection models
Johanna Olesk, Deborah L. Donahue, Jessica Ross, C P Sheehan, Zach Bennett, Kevin Armknecht, Carlie Kudary, Juliane Hopf, Victoria A. Ploplis, Francis Castellino, Shaun W. Lee, Prakash D. Nallathamby
Abstract
while showing immediate stabilization of the wound size, and infection free wound healing. Our results suggest the robust utility of antimicrobial peptide-conjugated phage-mimicking nanoparticles as a highly effective antibacterial system that can combat bacterial infections consistently while avoiding the emergence of resistant bacterial strains.
Topics & Concepts
AntimicrobialMicrobiologyStreptococcus pyogenesPeptideBacteriaAntimicrobial peptidesChemistryBiologyStaphylococcus aureusBiochemistryGeneticsAntimicrobial Peptides and ActivitiesBacteriophages and microbial interactionsBacterial biofilms and quorum sensing