Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties
Алиса Д. Морозова, Sean Chin Chan, Simon Bayle, Luxin Sun, Dylan Grassie, Anna Iermolaieva, Mahalakshmi N. Kalaga, Sylvia M. Frydman, Samer Sansil, E. Schönbrunn, Derek R. Duckett, Andrii Monastyrskyi
Topics & Concepts
ChemistryULK1In vivoAutophagyKinaseMAPK/ERK pathwayCell biologyIn vitroIntracellularIC50Protein kinase ACancer researchPharmacologyBiochemistryBiologyAMPKApoptosisBiotechnologyAutophagy in Disease and TherapyQuinazolinone synthesis and applicationsCalcium signaling and nucleotide metabolism