Genomic Landscapes of Epstein-Barr Virus in Pulmonary Lymphoepithelioma-Like Carcinoma
Yanxia Wu, Wenli Zhang, Tong‐Min Wang, Ying Liao, Yijun Zhang, Ruowen Xiao, Yijing Jia, Ziyi Wu, Changmi Deng, Da-Wei Yang, Wen‐Qiong Xue, Yong‐Qiao He, Xiao‐Hui Zheng, Xi‐Zhao Li, Ting Zhou, Pei‐Fen Zhang, Shaodan Zhang, Ye‐Zhu Hu, Jiangbo Zhang, Wei‐Hua Jia
Abstract
Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare, distinctive subtype of primary lung cancer closely associated with Epstein-Barr virus (EBV) infection. Here, we gave the first overview of pLELC-derived EBV at the level of genome, methylation and transcription. We obtained the EBV sequences data set from 78 primary pLELC patients, and revealed the sequences diversity across EBV genome and detected variability in known immune epitopes. Genome-wide association analysis combining 217 healthy controls identifies significant variations related to the risk of pLELC. Meanwhile, we characterized the integration landscapes of EBV at the genome-wide level. These results provided new insight for understanding EBV's role in pLELC tumorigenesis.