Physicochemical properties of abnormal blood acid-base buffering
Matthew B. Wolf
Abstract
This study represents the most up-to-date, physicochemical, multi-compartment computer model of the processes involved in determining the acid-base buffering state of blood. Previous models lack this capability, notably by being single compartment and/or lacking electroneutrality and osmotic constraints. Model results, analyzed from a different perspective of dependent [H + ] changes resulting from independent Pco 2 changes, provide a new set of Pco 2 -independent parameters, characteristic of blood buffering properties.
Topics & Concepts
Compartment (ship)Base (topology)ChemistryAcid–base homeostasisBiological systemBlood preservationBiophysicsBiochemistryBiologyPhysiologyMathematicsGeologyMathematical analysisOceanographyRenal function and acid-base balanceIon Transport and Channel RegulationThermodynamic properties of mixtures