Ruthenium-Catalyzed Site-Selective C–H Bond Activation/Annulation Cascade toward Dibenzoazepinone Skeletons
Deepan Chowdhury, Suman Dana, Subhankar Maity, Mahiuddin Baidya
Abstract
A free amine-directed ruthenium(II)-catalyzed hydroarylation and concomitant regioselective transamidation cascade between 2-aminobiphenyls and diversely substituted maleimides is reported, furnishing biologically relevant dibenzo[b,d]azepinone scaffolds in high yields. The protocol accommodates a range of functional groups and showcases synthesis of dibenzoazepinones bearing amino acid side chains through substrate design.
Topics & Concepts
ChemistryRutheniumAnnulationCatalysisCascadeAmine gas treatingRegioselectivityCombinatorial chemistrySubstrate (aquarium)Cascade reactionStereochemistryOrganic chemistryOceanographyGeologyChromatographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions