A multi pathway coupled domino strategy: I<sub>2</sub>/TBHP-promoted synthesis of imidazopyridines and thiazoles <i>via</i> sp<sup>3</sup>, sp<sup>2</sup> and sp C–H functionalization
Yishou Wang, Shichen Li, Xinfeng Wang, Yiming Yao, Lei Feng, Chen Ma
Abstract
/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.
Topics & Concepts
DominoChemistryCombinatorial chemistryMedicinal chemistryStereochemistryCatalysisOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation