Nickel<sup>II</sup>-catalyzed asymmetric photoenolization/Mannich reaction of (2-alkylphenyl) ketones
Liangkun Yang, Wang-Yuren Li, Liuzhen Hou, Tangyu Zhan, Weidi Cao, Xiaohua Liu, Xiaoming Feng
Abstract
in achieving high stereoselectivity was elucidated. This PEM reaction was proposed to undergo a direct nucleophilic addition mechanism rather than a hetero-Diels-Alder/ring-opening sequence. A possible transition state model with a photoenolization process was proposed to explain the origin of the high level of stereoinduction.
Topics & Concepts
ChemistryStereoselectivityEnantioselective synthesisMannich reactionNickelNucleophileCatalysisMedicinal chemistryLewis acids and basesCombinatorial chemistryStereochemistryOrganic chemistryRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods