LRP1 is a master regulator of tau uptake and spread
Jennifer N. Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef Sibih, Carolina Leshuk, Israel Hernández, Susanne Wegmann, Bradley T. Hyman, Viviana Gradinaru, Martin Kampmann, Kenneth S. Kosik
Topics & Concepts
LRP1Gene knockdownRegulatorDownregulation and upregulationCell biologyBiologyMicrotubuleFrontotemporal dementiaNeuroscienceEndocytosisInduced pluripotent stem cellTau proteinAlzheimer's diseaseDementiaCellDiseaseMedicineLDL receptorGeneticsCell cultureBiochemistryLipoproteinGenePathologyEmbryonic stem cellCholesterolAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and TreatmentsPrion Diseases and Protein Misfolding