Sema7A is crucial for resolution of severe inflammation
Andreas Körner, Alice Bernard, Julia C. Fitzgerald, Juan Carlos Alarcon-Barrera, Sarantos Kostidis, Torsten Kaussen, Martin Giera, Valbona Mirakaj
Abstract
Significance Nonresolving inflammation, a hallmark of sepsis and/or multi-organ failure, still poses a challenge in medicine. The mortality rate is enormous, and so far no adequate curative therapy is available. Here we identify a previously unrecognized role of the neuronal guidance protein semaphorin 7A in the transition to resolution processes in severe systematic inflammation such as sepsis.
Topics & Concepts
InflammationSepsisMedicineIntensive care medicineImmunologyBioinformaticsBiologyAxon Guidance and Neuronal SignalingApelin-related biomedical researchBiomarkers in Disease Mechanisms