R-loops coordinate with SOX2 in regulating reprogramming to pluripotency
Yaoyi Li, Yawei Song, Wei Xu, Qin Li, Xinxiu Wang, Kuan Li, Juehan Wang, Zicong Liu, Sergiy Velychko, Rong Ye, Qing Xia, Lei Wang, Rong Guo, Xiaotao Dong, Zhikai Zheng, Yushuang Dai, Haojie Li, Mingze Yao, Yuanchao Xue, Hans R. Schöler, Qianwen Sun, Hongjie Yao
Abstract
targeting the specific R-loop regions. Together, these results show that R-loops play important roles in reprogramming and shed light on the regulatory module of Sox2/Ddx5 on R-loops during reprogramming.
Topics & Concepts
ReprogrammingSOX2Cell biologyComputer scienceBiologyComputational biologyGeneticsEmbryonic stem cellCellGeneCRISPR and Genetic EngineeringPluripotent Stem Cells ResearchGenomics and Chromatin Dynamics