Oxidative stress induced conformational changes of human serum albumin
Debdip Brahma, Akshay Narayan Sarangi, Rupal Kaushik, Amar Nath Gupta
Abstract
aggregation. The CD and FTIR spectra indicate the associated secondary structural changes occurring with time, depicting the variation of the helical content of HSA. The amide-III analysis of Raman data also complements the structural changes, and MALDI-TOF data show the mass distribution with time. Overall, this work might help determine the effect of oxidation on the biological activity of serum albumin as it can impact the physiological properties of HSA.
Topics & Concepts
Oxidative stressReactive oxygen speciesOxidative phosphorylationChemistryBiophysicsAlbuminSerum albuminOxygenBiochemistryBiologyOrganic chemistryProtein Interaction Studies and Fluorescence AnalysisAdvanced Glycation End Products researchAlzheimer's disease research and treatments