Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC
Tao Pan, Yan Rong Dan, Dafeng Guo, Junhao Jiang, Dongzhi Ran, Lin Zhang, Binghua Tian, Jianyong Yuan, Yu Yu, Zongjie Gan
Topics & Concepts
CeritinibCrizotinibAnaplastic lymphoma kinaseChemistryALK inhibitorPharmacophoreCancer researchApoptosisCell cultureCell cycleCell cycle checkpointLung cancerBiochemistryBiologyMedicineInternal medicineGeneticsMalignant pleural effusionLung Cancer Treatments and MutationsHistone Deacetylase Inhibitors ResearchCancer therapeutics and mechanisms