Laser Ablation Synthesis in Solution and Nebulization of Silver-109 Nanoparticles for Mass Spectrometry and Mass Spectrometry Imaging
Aneta Płaza‐Altamer, Artur Kołodziej, Joanna Nizioł, Tomasz Ruman
Abstract
AgNPs) by pulsed fiber laser (PFL) ablation synthesis in solution (LASiS) with the use of a 2D galvoscanner (2D GS) is described. The procedure of covering of custom-made stainless-steel MALDI targets containing studied objects via nebulization is also presented. Examples of application of the new method (PFL-2D GS LASiS and nebulization) in mass spectrometry (MS) analyses and MS imaging (MSI) are shown. These include tests with a nonionic nucleoside and saccharide, ionic amino acids, and also a low-molecular-weight polymer. Fingerprint MS imaging is shown as an example of a fast and simple MSI procedure.
Topics & Concepts
Monoisotopic massMass spectrometryMass spectrometry imagingLaser ablationChemistryMALDI imagingLaser ablation synthesis in solutionChromatographyNanoparticleAnalytical Chemistry (journal)AblationLaserMaterials scienceMatrix-assisted laser desorption/ionizationNanotechnologyOpticsOrganic chemistryDesorptionX-ray laserPhysicsAdsorptionEngineeringLaser power scalingAerospace engineeringMass Spectrometry Techniques and ApplicationsIon-surface interactions and analysisForensic Fingerprint Detection Methods