Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors
Shoiab Bukhari, Brian S. Henick, Robert Winchester, Shalom Lerrer, Kieran Adam, Yevgeniya Gartshteyn, Rohan Maniar, Ziyan Lin, Alireza Khodadadi‐Jamayran, Aristotelis Tsirigos, Mary Salvatore, Galina Lagos, Steven L. Reiner, Matthew C. Dallos, Matthen Mathew, Naiyer A. Rizvi, Adam Mor
Abstract
cells when compared with patients who do not develop irAEs. These data support the hypothesis that different populations of T cells are associated with different irAEs and that characterization of these cells' pre-treatment has the potential to serve as a toxicity-specific predictive biomarker.
Topics & Concepts
BiologyImmune systemCellRNAImmune checkpointAdverse effectComputational biologyVirologyGeneticsGeneImmunotherapyPharmacologyCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmune Cell Function and Interaction