Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila
Stephanie E. Hood, Xeniya V. Kofler, Quiyu Chen, Judah Scott, Jason Ortega, Michael Lehmann
Abstract
flies. Altogether, our data suggest that the nuclear activity of Lipin influences the genomic response to nutrient availability with effects on life expectancy and starvation resistance. Thus, nutritional or therapeutic approaches that aim at lowering nuclear translocation of lipins in humans may be worth exploring.
Topics & Concepts
BiologyCell biologyChromosomal translocationMutantNuclear localization sequenceGeneGene expressionNuclear export signalCell nucleusGeneticsCytoplasmLipid metabolism and biosynthesisInsect Resistance and GeneticsNeurobiology and Insect Physiology Research