Carbon-ion Radiotherapy for Inoperable Head and Neck Bone and Soft-tissue Sarcoma: Prospective Observational Study
Atsushi Musha, Nobuteru Kubo, Hidemasa Kawamura, Naoko Okano, Hiro Sato, K Okada, Naoto Osu, Hikaru Yumisaki, Akiko Adachi, Yukihiro Takayasu, Masato Shino, Osamu Nikkuni, Shota Ida, Katsuyuki Shirai, Jun‐ichi Saitoh, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno
Abstract
BACKGROUND/AIM: Bone and soft-tissue sarcomas of the head and neck have very poor prognoses. This prospective study aimed to investigate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for bone and soft-tissue sarcoma of the head and neck. PATIENTS AND METHODS: The present study was a prospective clinical study that included 10 consecutive patients diagnosed with bone and soft-tissue sarcoma of the head and neck who were treated with C-ion RT between 2012 and 2018 at our institution. C-Ion RT consisted of 70.4 Gy (relative biological effectiveness) in 16 fractions. RESULTS: The 3-year local control, overall survival, and progression-free survival rates for patients overall were 72.9%, 77.8%, and 36%, respectively. CONCLUSION: The present study demonstrated the efficacy of C-ion RT for bone and soft-tissue sarcoma of the head and neck; adverse events were within the expected range.