Antibiotics Limit Adaptation of Drug-Resistant Staphylococcus aureus to Hypoxia
Rebecca C Hull, Rosanna C. T. Wright, Jon R. Sayers, Joshua A. F. Sutton, J Rzaska, Simon J. Foster, Michael A. Brockhurst, Alison M. Condliffe
Abstract
, was impeded by antibiotic treatment. Together, these data suggest that the horizontal acquisition of a new resistance mechanism is merely a starting point for the emergence of high-level resistance under antibiotic selection but that antibiotic treatment constrains pathogen adaptation to other important environmental selective forces such as hypoxia, which in turn could limit the survival of these highly resistant but poorly adapted genotypes after antibiotic treatment is ended.
Topics & Concepts
TetracyclineAntibioticsStaphylococcus aureusAntibiotic resistanceBiologyMicrobiologyDoxycyclineEffluxDrug resistanceMethicillin-resistant Staphylococcus aureusBacteriaGeneticsBacterial Identification and Susceptibility TestingAntibiotic Resistance in BacteriaBacteriophages and microbial interactions