Ligand-directed bias of G protein signaling at the dopamine D2 receptor
Ee Von Moo, Kasper Harpsøe, Alexander S. Hauser, Ikuo Masuho, Hans Bräuner‐Osborne, David E. Gloriam, Kirill A. Martemyanov
Topics & Concepts
G protein-coupled receptorHeterotrimeric G proteinDopamine receptor D2Functional selectivityG proteinReceptorLigand (biochemistry)Dopamine receptorBiologyComputational biologyChemistryBiochemistryReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyProtein Kinase Regulation and GTPase Signaling