Rhodamine-Based Metal Chelator: A Potent Inhibitor of Metal-Catalyzed Amyloid Toxicity
Krishnangsu Pradhan, Gaurav Das, Chirantan Kar, Nabanita Mukherjee, Juhee Khan, Tanushree Mahata, Surajit Barman, Surajit Ghosh
Abstract
-induced cytotoxicity. All these results support the multifunctional nature of Rh-BT, which has an Aβ-specific recognition unit. In addition to the above properties, Rh-BT also exhibits good serum stability in vivo and blood-brain barrier permeability. Therefore, Rh-BT can be considered as a potent multifunctional therapeutic for the treatment of AD.
Topics & Concepts
ChelationMetal toxicityToxicityChemistryMetalRhodamine BRhodamineCatalysisPharmacologyBiochemistryMedicineOrganic chemistryFluorescenceQuantum mechanicsPhotocatalysisPhysicsAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods