Role of phosphatidylserine in amyloid-beta oligomerization at asymmetric phospholipid bilayers
J. B. D. Robinson, Nirod Kumar Sarangi, Tia E. Keyes
Abstract
Damage to a lipid bilayer induced by laser photons induces DOPS to translocate from the inner leaflet to the outside leaflet, so setting off amyloid-beta binding and oligomer formation.
Topics & Concepts
MembraneBiophysicsPhosphatidylserineChemistryLipid bilayerCell membranePhospholipidBiochemistryBiologyAlzheimer's disease research and treatmentsLipid Membrane Structure and BehaviorDrug Transport and Resistance Mechanisms