The signatures of liver metabolomics and gut microbiota in high-fat diet fed mice supplemented with rhododendrol

Abstract

. Liver metabolomics analysis indicated that RHO enhanced the abundance of metabolites related to alanine, aspartate, and glutamate metabolism, as well as arginine and proline metabolism. Spearman correlation analysis revealed that these metabolites were positively correlated with the gut genera enriched by RHO. Here, our findings suggested that the metabolic effects of RK might be partially attributed to its metabolite-RHO, and mice supplemented with RHO have dramatically altered hepatic metabolisms concurrent with shifts in specific gut bacteria.

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