Placement of tyrosine residues as a design element for tuning the phase transition of elastin-peptide-containing conjugates: experiments and simulations
Phillip A. Taylor, Haofu Huang, Kristi L. Kiick, Arthi Jayaraman
Abstract
This study uses simulations and experiments to explain why and how the placement of tyrosine residues in elastin-peptide containing conjugates impacts their transition temperature.
Topics & Concepts
ConjugateElastinTyrosinePeptidePhase transitionTransition (genetics)ChemistryPhase (matter)BiophysicsMaterials scienceBiochemistryOrganic chemistryThermodynamicsMathematicsPhysicsBiologyGeneticsGeneMathematical analysisConnective tissue disorders researchCell Adhesion Molecules ResearchProtease and Inhibitor Mechanisms