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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Wensheng Yu, Jian Liu, Younong Yu, Vivian Zhang, Dane J. Clausen, Joseph Kelly, S. E. Wolkenberg, Douglas C. Beshore, Joseph Duffy, Christine C. Chung, Robert W. Myers, Daniel J. Klein, James I. Fells, Kate Holloway, Jin Wu, Guoxin Wu, Bonnie J. Howell, Richard J. O. Barnard, Joseph A. Kozlowski

2020Bioorganic & Medicinal Chemistry Letters27 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryKetonePotencySelectivityAmideEnzymeStereochemistryChemical synthesisCombinatorial chemistryBiochemistryOrganic chemistryIn vitroCatalysisHIV/AIDS drug development and treatmentHIV Research and TreatmentHistone Deacetylase Inhibitors Research
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