Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation
Wensheng Yu, Jian Liu, Younong Yu, Vivian Zhang, Dane J. Clausen, Joseph Kelly, S. E. Wolkenberg, Douglas C. Beshore, Joseph Duffy, Christine C. Chung, Robert W. Myers, Daniel J. Klein, James I. Fells, Kate Holloway, Jin Wu, Guoxin Wu, Bonnie J. Howell, Richard J. O. Barnard, Joseph A. Kozlowski
Topics & Concepts
ChemistryKetonePotencySelectivityAmideEnzymeStereochemistryChemical synthesisCombinatorial chemistryBiochemistryOrganic chemistryIn vitroCatalysisHIV/AIDS drug development and treatmentHIV Research and TreatmentHistone Deacetylase Inhibitors Research