The Signaling Pathway of PGE<sub>2</sub> and Its Regulatory Role in T Cell Differentiation
Yang An, Jiameng Yao, Xiaoyin Niu
Abstract
Prostaglandin E2 (PGE 2 ) is a lipid mediator derived from the fatty acid arachidonic acid. As an essential inflammatory factor, PGE 2 has a critical impact on immune regulation through the prostanoid E (EP) receptor pathway. T cells, including CD4 + and CD8 + T cell subsets, play crucial roles in the adaptive immune response. Previous studies have shown that PGE 2 is involved in regulating CD4 + T cell differentiation and inflammatory cytokine production via the EP receptor pathway, thereby affecting the development of diseases mediated by CD4 + T cells. In this review, we summarize the signaling pathway of PGE 2 and describe the relationship between PGE 2 and T cell differentiation. Hence, this review may provide important evidence for immune therapies and may even promote the development of biomedicines.