Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
Cherrelle Dacon, Linghang Peng, Ting-Hui Lin, Courtney Tucker, Chang‐Chun D. Lee, Yu Cong, Lingshu Wang, Lauren Purser, Andrew J. R. Cooper, Jazmean K. Williams, Chul‐Woo Pyo, Meng Yuan, Ivan Košík, Zhe Hu, Ming Zhao, Divya Mohan, Mary Peterson, Jeff Skinner, Saurabh Dixit, Erin Kollins, Louis Huzella, Donna L. Perry, Russell Byrum, Sanae Lembirik, Michael Murphy, Yi Zhang, Eun Sung Yang, Man Chen, Kwanyee Leung, Rona Singer Weinberg, Amarendra Pegu, Daniel E. Geraghty, Edgar Davidson, Benjamin J. Doranz, Iyadh Douagi, Susan Moir, Jonathan W. Yewdell, Connie S. Schmaljohn, Peter D. Crompton, John R. Mascola, Michael R. Holbrook, David Nemazee, Ian A. Wilson, Joshua Tan
Abstract
(Cell Host & Microbe 31, 97–111.e1–e12; January 11, 2023) In Figure 6A, the authors discovered after publication that the neutralization NT50 values of two similar IGHV1-46/IGKV3-20 mAbs (COV30-14 and COV72-37) for several SARS-CoV-2 variants were switched due to a copying error. This correction does not impact the conclusions of the original paper. The affected NT50 values of the two mAbs only differed <2 fold. The authors regret the inconvenience caused by this error, which has been corrected in the original article online. Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronavirusesDacon et al.Cell Host & MicrobeNovember 7, 2022In BriefThe characteristics of antibodies that broadly neutralize coronaviruses are poorly understood. Here, Dacon et al. identify a class of stem helix-specific monoclonal antibodies from COVID-19 convalescent donors that neutralize diverse betacoronaviruses, use an IGHV1-46/IGKV3-20 gene signature, and bind in a conserved manner to the spike protein. Full-Text PDF Open Access