Glioblastoma cell differentiation trajectory predicts the immunotherapy response and overall survival of patients
Zihao Wang, Xiaopeng Guo, Lu Gao, Yu Wang, Wenbin Ma, Bing Xing
Abstract
were the 4 most significant survival-predicting GDRGs, and patients with different expression levels of each of these genes had distinct survival outcomes. Finally, a nomogram composed of the GDRG signature, age, pharmacotherapy, radiotherapy, IDH mutations and MGMT promoter methylation was generated and validated in two large GBM cohorts to predict GBM prognosis. This study highlights the significant roles of cell differentiation in predicting the clinical outcomes of GBM patients and their potential response to immunotherapy, suggesting promising therapeutic targets for GBM.
Topics & Concepts
ImmunotherapyTemozolomideTranscriptomeBiologyOncologyImmune systemCancer researchNomogramSurvival analysisMedicineGeneGliomaGene expressionImmunologyInternal medicineGeneticsSingle-cell and spatial transcriptomicsGlioma Diagnosis and TreatmentNeuroinflammation and Neurodegeneration Mechanisms