NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
Ángel Cores, Marta Piquero, Mercedes Villacampa, Rafael León, J. Carlos Menéndez
Abstract
NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
Topics & Concepts
RegulatorMaster regulatorTranscription factorNeuroinflammationProteasomeTranscriptional regulationTranscription (linguistics)Regulation of gene expressionDrugBiologyDrug discoveryComputational biologyDrug targetCell biologyNeuroscienceGeneBioinformaticsPharmacologyGeneticsImmunologyInflammationLinguisticsPhilosophyGenomics, phytochemicals, and oxidative stressCoenzyme Q10 studies and effectsFree Radicals and Antioxidants