Drug Repositioning Using Computer-aided Drug Design (CADD)
S. Rawat, Kanmani Subramaniam, Selva Kumar Subramanian, Subbarayan Saravanan, Subramanian Dhanabalan, Sashik Kumar Madurai Chidambaram, B. Stalin, Arpita Roy, N. Nagaprasad, M. Aruna, Jule Leta Tesfaye, Bayissa Badassa, Ramaswamy Krishnaraj
Abstract
Drug repositioning is a method of using authorized drugs for other unusually complex diseases. Compared to new drug development, this method is fast, low in cost, and effective. Through the use of outstanding bioinformatics tools, such as computer-aided drug design (CADD), computer strategies play a vital role in the re-transformation of drugs. The use of CADD's special strategy for target-based drug reuse is the most promising method, and its realization rate is high. In this review article, we have particularly focused on understanding the various technologies of CADD and the use of computer-aided drug design for target-based drug reuse, taking COVID-19 and cancer as examples. Finally, it is concluded that CADD technology is accelerating the development of repurposed drugs due to its many advantages, and there are many facts to prove that the new ligand-targeting strategy is a beneficial method and that it will gain momentum with the development of technology.