Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods
Federica Fogacci, Valentina Di Micoli, Ashot Avagimyan, Marina Giovannini, Egidio Imbalzano, Arrigo F.G. Cicero
Abstract
Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of genetics in establishing Lp(a) as a risk factor for coronary heart disease (CHD) by examining a series of molecular biology techniques aimed at identifying the best strategy for a possible application in clinical research and practice, according to the current gold standard.
Topics & Concepts
Apolipoprotein BLipoprotein(a)Gene isoformGenotypePhenotypeLipoproteinComputational biologyBiologyGeneticsGeneCoronary heart diseaseBioinformaticsMedicineInternal medicineEndocrinologyCholesterolLipoproteins and Cardiovascular HealthCancer, Lipids, and MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins