Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19
Christoph Schultheiß, Lisa Paschold, Edith Willscher, Donjetë Simnica, Anna Wöstemeier, Franziska Muscate, Maxi Wass, Stephan Eisenmann, Jochen Dutzmann, Gernot Keyßer, Nicola Gagliani, Mascha Binder
Abstract
) with immunogenetic and transcriptional signs of autoreactivity that may be the cellular source of autoantibodies in COVID-19 and that may persist beyond recovery. Immunomodulatory interventions discouraging such adverse responses may be useful in selected patients to shift the balance from autoreactivity toward long-term memory.
Topics & Concepts
Germinal centerImmunologyAutoimmunityBiologyAutoantibodyCXCR5B-cell activating factorCD80B cellAntibodyCD40GeneticsCytotoxic T cellIn vitroSARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinationsCOVID-19 Clinical Research Studies