Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes
Naser Jafari, Manohar Kolla, Tova Meshulam, Jordan Shafran, Yuhan Qiu, Allison N. Casey, Isabella R. Pompa, Christina Ennis, Carla Mazzeo, Nabil Rabhi, Stephen R. Farmer, Gerald V. Denis
Abstract
correlated with poorer prognosis, specifically decreased distant metastasis–free survival. Our findings reveal a mechanism of exosome-mediated cross-talk between metabolically abnormal adipocytes and breast cancer cells that may promote tumor aggressiveness in patients with T2D.
Topics & Concepts
MicrovesiclesAdipocyteType 2 diabetesMetastasisBreast cancerCancer researchCancerMedicineInternal medicineDiabetes mellitusEndocrinologyBiologymicroRNAAdipose tissueBiochemistryGeneExtracellular vesicles in diseaseAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases